Survivin Promotes Piperlongumine Resistance in Ovarian Cancer
Identifieur interne : 000415 ( Main/Exploration ); précédent : 000414; suivant : 000416Survivin Promotes Piperlongumine Resistance in Ovarian Cancer
Auteurs : Xing-Wei Nan [République populaire de Chine] ; Li-Hua Gong [République populaire de Chine] ; Xu Chen [République populaire de Chine] ; Hai-Hong Zhou [République populaire de Chine] ; Piao-Piao Ye [République populaire de Chine] ; Yang Yang [République populaire de Chine] ; Zi-Hao Xing [République populaire de Chine] ; Meng-Ning Wei [République populaire de Chine] ; Yao Li [République populaire de Chine] ; Sheng-Te Wang [République populaire de Chine] ; Kun Liu [République populaire de Chine] ; Zhi Shi [République populaire de Chine] ; Xiao-Jian Yan [République populaire de Chine]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
Ovarian cancer is one of the most fatal female malignancies while targeting apoptosis is critical for improving ovarian cancer patients' lives. Survivin is regarded as the most robust anti-apoptosis protein, and its overexpression in ovarian cancer is related to poor survival and apoptosis resistance. Piperlongumine (PL) extracted from peppers is defined as an active alkaloid/amide and exhibits a broad spectrum of antitumor effects. Here, we demonstrate that PL induces the rapid depletion of survivin protein levels via reactive oxygen species (ROS)-mediated proteasome-dependent pathway
Url:
DOI: 10.3389/fonc.2019.01345
PubMed: 31850227
PubMed Central: 6895030
Affiliations:
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University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Sheng Te" sort="Wang, Sheng Te" uniqKey="Wang S" first="Sheng-Te" last="Wang">Sheng-Te Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Kun" sort="Liu, Kun" uniqKey="Liu K" first="Kun" last="Liu">Kun 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Medicine</institution>,<addr-line>Hangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31850227</idno><idno type="pmc">6895030</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895030</idno><idno type="RBID">PMC:6895030</idno><idno type="doi">10.3389/fonc.2019.01345</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000566</idno><idno type="wicri:Area/Pmc/Curation">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000566</idno><idno type="wicri:Area/Pmc/Checkpoint">000374</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000374</idno><idno 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sort="Gong, Li Hua" uniqKey="Gong L" first="Li-Hua" last="Gong">Li-Hua Gong</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xu" sort="Chen, Xu" uniqKey="Chen X" first="Xu" last="Chen">Xu Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Hai Hong" sort="Zhou, Hai Hong" uniqKey="Zhou H" first="Hai-Hong" last="Zhou">Hai-Hong Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Piao Piao" sort="Ye, Piao Piao" uniqKey="Ye P" first="Piao-Piao" last="Ye">Piao-Piao Ye</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xing, Zi Hao" sort="Xing, Zi Hao" uniqKey="Xing Z" first="Zi-Hao" last="Xing">Zi-Hao Xing</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wei, Meng Ning" sort="Wei, Meng Ning" uniqKey="Wei M" first="Meng-Ning" last="Wei">Meng-Ning Wei</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yao" sort="Li, Yao" uniqKey="Li Y" first="Yao" last="Li">Yao Li</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Sheng Te" sort="Wang, Sheng Te" uniqKey="Wang S" first="Sheng-Te" last="Wang">Sheng-Te Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Kun" sort="Liu, Kun" uniqKey="Liu K" first="Kun" last="Liu">Kun Liu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Zhi" sort="Shi, Zhi" uniqKey="Shi Z" first="Zhi" last="Shi">Zhi Shi</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Xiao Jian" sort="Yan, Xiao Jian" uniqKey="Yan X" first="Xiao-Jian" last="Yan">Xiao-Jian Yan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine</institution>,<addr-line>Hangzhou</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Oncology</title><idno type="eISSN">2234-943X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ovarian cancer is one of the most fatal female malignancies while targeting apoptosis is critical for improving ovarian cancer patients' lives. Survivin is regarded as the most robust anti-apoptosis protein, and its overexpression in ovarian cancer is related to poor survival and apoptosis resistance. Piperlongumine (PL) extracted from peppers is defined as an active alkaloid/amide and exhibits a broad spectrum of antitumor effects. Here, we demonstrate that PL induces the rapid depletion of survivin protein levels via reactive oxygen species (ROS)-mediated proteasome-dependent pathway <italic>in vitro</italic>, while exerting a remarkable inhibitory influence on the proliferation of ovarian cancer cells. Overexpression of survivin raises the survival rate of ovarian cancer cells to PL. Moreover, PL inhibits ovarian cancer cells xenograft tumor growth and downregulates survivin <italic>in vivo</italic>. Our findings reveal a previously unrecognized mechanism of PL in suppressing survivin expression as well as survivin promotes piperlongumine resistance in ovarian cancer and suggest that ROS-mediated proteasome-dependent pathway can be exploited to overcome apoptosis resistance triggered by aberrant expression of survivin.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Reid, Bm" uniqKey="Reid B">BM Reid</name></author><author><name sortKey="Permuth, Jb" uniqKey="Permuth J">JB Permuth</name></author><author><name sortKey="Sellers, Ta" uniqKey="Sellers T">TA Sellers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torre, La" uniqKey="Torre L">LA Torre</name></author><author><name sortKey="Trabert, B" uniqKey="Trabert B">B Trabert</name></author><author><name sortKey="Desantis, Ce" uniqKey="Desantis C">CE DeSantis</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD 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Chine"><noRegion><name sortKey="Nan, Xing Wei" sort="Nan, Xing Wei" uniqKey="Nan X" first="Xing-Wei" last="Nan">Xing-Wei Nan</name></noRegion><name sortKey="Chen, Xu" sort="Chen, Xu" uniqKey="Chen X" first="Xu" last="Chen">Xu Chen</name><name sortKey="Gong, Li Hua" sort="Gong, Li Hua" uniqKey="Gong L" first="Li-Hua" last="Gong">Li-Hua Gong</name><name sortKey="Li, Yao" sort="Li, Yao" uniqKey="Li Y" first="Yao" last="Li">Yao Li</name><name sortKey="Liu, Kun" sort="Liu, Kun" uniqKey="Liu K" first="Kun" last="Liu">Kun Liu</name><name sortKey="Shi, Zhi" sort="Shi, Zhi" uniqKey="Shi Z" first="Zhi" last="Shi">Zhi Shi</name><name sortKey="Wang, Sheng Te" sort="Wang, Sheng Te" uniqKey="Wang S" first="Sheng-Te" last="Wang">Sheng-Te Wang</name><name sortKey="Wei, Meng Ning" sort="Wei, Meng Ning" uniqKey="Wei M" first="Meng-Ning" last="Wei">Meng-Ning Wei</name><name sortKey="Xing, Zi Hao" sort="Xing, Zi Hao" uniqKey="Xing Z" first="Zi-Hao" last="Xing">Zi-Hao Xing</name><name sortKey="Yan, Xiao Jian" sort="Yan, Xiao Jian" uniqKey="Yan X" first="Xiao-Jian" last="Yan">Xiao-Jian Yan</name><name sortKey="Yan, Xiao Jian" sort="Yan, Xiao Jian" uniqKey="Yan X" first="Xiao-Jian" last="Yan">Xiao-Jian Yan</name><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name><name sortKey="Ye, Piao Piao" sort="Ye, Piao Piao" uniqKey="Ye P" first="Piao-Piao" last="Ye">Piao-Piao Ye</name><name sortKey="Zhou, Hai Hong" sort="Zhou, Hai Hong" uniqKey="Zhou H" first="Hai-Hong" last="Zhou">Hai-Hong Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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